TO MY NEW STUDENTS
Interview directed by
Gustavo Fernandez in "The Review”, Cultural Radio, Puerto Vallarta, Jalisco’s
System of Radio and Television. Friday,
Jun 29, 2007.
GF - … I think that starting at this moment we are going to
have a conversation for which we are going to ask you most specially to put all
the attention as Fernando Castro Chavez is joining us, he is specialist in
molecular biology and well, for the very few words that we exchanged in a
minute, I think there is not going to be a second that we could miss in this
dialog with Fernando. Thank you, Fernando for visiting us, and welcome; and
well, molecular biology, genetics, present, future, here we have mixed so many
things.
fdocc – Yes, and specially, I am happy that you had received
me, thank you very much, and we can start by defining molecular biology.
GF – What’s your specialty?
fdocc – Well, the Ph.D. is in molecular biology, but before
I did a master’s degree in biotechnology.
GF - What is molecular biology?
fdocc – Molecular biology is the study of the structure of
genes and their function. It is, going to the smallest part of existence which
is functional to sustain life.
GF - ¿What do you discover studying genes? ¿What could we
find studying genetics; well, we are interested in humans but in reality it is
in everything?, because, every living being has genetics.
fdocc – Yes, of course. For
example, we can see single analogies able to illustrate us the means and the
area for this specialty. In fruit flies, we ask ourselves, is this small red
eyed fly able to remember things?, to memorize things? Then, scientists put in
one side a smell coupled to an electric discharge and in the other side,
another smell without electricity, and they see if the fly is capable to relate
the smell with electricity and not go to that location, but to the opposite
side. After that, the scientist alters the genes using some mutagens when the
flies are very small and they find out if the fly is amnesia being unable to
remember the difference between the smell coupled to electricity and the smell
without electricity, the scientist studies which is exactly the altered gene,
and in that way it is possible to define the location of the genetic
information involved with memory; and the surprising thing is that even the
smallest animals, including bacteria, are able to remember things and to move
accordingly.
GF - ¿Which benefits can this
bring to human genetics?, because we know, for example, that already there are,
and I have seen it, for example, the sell of fluorescent fishes, in United
States, you are coming from there…
fdocc – Yes.
GF - … rabbits with pink hair, I don’t know, such
kina of things genetically obtainable, but which benefits, apart of this show a
little bit of bad taste could be attained, ¿which benefits it offers to the
human being?
fdocc - Yes, unfortunately the
bad taste is altering such genes, but that’s the only way to learn where are
them located. In the case of small animals, well, those are the ones that, so
to speak, are teaching us, offering us such knowledge. In the case of humans,
genes are more complex, with more variations, and based in what we learn from
those animals, we could be able to infer some things for the human organism,
and very carefully, to try, in humans, not to destroy genes, but to look for a
way to reversibly inhibit some noxious genes. For example, in the case of
obesity, the last study I did in the U. S. consists in a protein called
"perilipin”, which means, "surrounding lipids” and is the protein located in
the storage box of your fatty cells.
GF – In the belly
fdocc – Exactly there, in male
and a little lower in women, and what we discovered is that if we cut
deliberately such gene in mice, no matter how much fat the little mouse ingests
or more carbohydrates, never will it get fatty, it keeps itself lean, meager
and with strong muscles.
GF – Well, that will be
hyper-excellent for us.
fdocc – Of course, there is a
little collateral effect, as God knows why he put such storage systems …
GF – Yes.
fdocc - …and the animal which
lacks of the storage units, if it stays for a long time at low temperatures,
for example, eight hours at four degrees, is able to start freezing if lacking
food. Then, it needs food, eating almost twice the wild-type animal, but it
survives if in the refrigerator it is food available.
GF – Well, here we have two
topics that you touched passing by but that I will like you to tell us
something about them.
fdocc – Yes.
GF – When you mentioned creation,
that God knows why he did things. It is the religious concept involved in
science and science with religion in these topics?
fdocc – Well, for example, what
happens is that researchers have personal convictions, and based on those they
can develop research. For example, in my case, in my conviction, in my belief
in a God creator, I can in such a way to see the order, and try to find out
what altered such order, and to try to revert it. For example, in humans, it
has been investigated that natives of the north of Mexico, the Pima Indians, in the
environment in which they live they are perfectly adapted, through exercise and
activity, and all the movement they do during the day. But if they move to United States,
they cross the border, their diet changes, they move to an environment totally
sedentary, and they became getting obese. Then, the key is in identifying what
is normality and how to revert to normal for humans, as in this case, this
tribe of the north of Mexico,
they need to do more exercise.
GF – Yes, science knows for example
genetic studies, for what are you telling us, of people in a region; for
example, can we say that we already know the genetics of Mexicans?
fdocc – Yes, it is known in part
and there have been selected specific genes; for example, what I was investigating
in Guadalajara,
in the Civil Hospital, with Doctor Arturo Panduro, he
is looking at the small genetic variations that are making the different
Mexican native populations from different tribes, more susceptible to
alcoholism. Then, he have found that with some genetic modifications,
technically called "polymorphism”, some people have smaller enzyme’s mouths
degrading alcohol, being for that reason incapable of degrading it on time and
it stays stationary, and it accumulates in the liver, with which there are high
problems of developing cirrhosis when compared with other populations.
GF - Where did you develop your
research in the United
States?
fdocc – Well, we studied in the
Baylor Collage of Medicine, which is in touch with the Guadalajara University,
but the biggest desire is to be able to launch this molecular research here in Puerto Vallarta. Because,
if we were able to say that there is a living laboratory rich in biological
resources, plants and animals…more than Guadalajara itself, it is here, on the
beach.
GF – "It is here, on the beach”,
and related to the current and concrete benefits that you could be able to
mention us related to chronic-degenerative diseases or some other malady, as
you mentioned alcoholism, but that could be applied now for the normal patient
in relation to genetics, what can you tell us?.
fdocc – Certainly, for example
from molecular biology studies it was discovered that apart of the insulin
injection, there is another alternative which is an oral medicament, I won’t
provide the commercial name, but there is already oral medicine to counteract
Diabetes…
GF – ¡There is such medicament!
fdocc – …And was based on
molecular biology. Then, it saves Diabetic people the pain of insulin
injections every day through this oral ingestion …
GF – So, that is with a small
oral capsule …
fdocc – Yes, it can be one in the
morning, another in the night, and when the person is normalized, it is
possible to reduce the consumption of this capsule and to try to improve diet
and exercise. Because all of these medicaments unfortunately make the person
addictive to them, which means, an obese person desiring to get lean with a
reversible inhibitor to be discovered, that we may be able to discover, God
first, will depend on such substance to lower its weight, and when that person
stops taking it, the process will start reverting if the person lacks of the
education to eat correctly and the will to do exercise. This is then a
combination of things, first, it will be to provide the treatment, then, when
the person gets excited looking how it gets lean again, to teach her how to eat
correctly, small amounts, and to do exercise, to increase the activity.
GF – I don’t say it is difficult
to believe because we are talking about science, but really the diet that we
have here in Mexico is not helpful to achieve that modifying, it won’t be so
easy what you are saying because we are totally used to eat carbohydrates, fats
and the most the best because we enjoy it more.
fdocc – Certainly, and we go to
the U. S.
and the diet there is even worse.
GF – (smile)
fdocc – The irony is, for
example, we have antiobesity congresses in the United States and in the breaks
they provide slices of de pizza, donuts…
GF – (SMILE)
fdocc – Which is to say, the key
relies in the will of the person and I think that no matter how many medicines
will be discovered, if a person lacks the will, she will revert to obesity, or
will became a dependent on chemicals, a medical substance able to help her on
reducing weight.
GF – In what we talked before we
entered to the microphone, we saw that all these advances, this genetic and
molecular manipulation is welcome, but if it falls in hands of people that is
going to use it in benefit of humanity. That’s a very delicate topic with
ethics in between.
fdocc – Indeed, absolutely. To us
researchers it is really discouraging when higher powers in the sense of more
political, with more economy than the researcher, they take it for their
personal means and then, they hide it for the higher classes and not provide it
to the general population, or they use it for their particular ends, and this
is sad.
GF – And unfortunately it is
something that happens …
fdocc – Yes…
GF - … I say, without specifying
particulars, but that’s something present to be very careful about, ¿no?
fdocc – Of course, and with
extreme discretion and wisdom to try to counteract it, without a total
exposure.
GF - ¿Do we have already
available genetic modifications useful for man in his daily life, that we are
using without knowing it, are those already here?
fdocc – For example, many foods
already have genetic advantages, including if only obtained through selection,
I mean, I agree that before using aggressive technologies in the laboratory, we
have the beauty of Mendel methods for genetic improvement, where you for
example select the bigger tomatoes and from there you have better production,
or you select cows producing milk and you obtain a better yield. It is to say
that with the simple cross-breeding methods, which is a key forgotten for many
people because is time consuming and work intense, you can even obtain new
varieties of organisms.
GF – Now that you mention milk, I
want to ask, in a TV program they said that in South
America there are cows that are producing milk for diabetics,
which means that now with that milk they don’t need to receive the insulin
injection, similar to what you commented before.
fdocc – Certainly.
GF – Then it called my attention
because it is to obtain an animal producing something specific to provide for a
need.
fdocc – Yes, in that case the
gene producing a substance is inserted and then, when people drinks that milk,
the medicine is already there, it’s like instead of swallowing the capsule that
we commented before to counteract diabetes, instead of the injection of
insulin...
GF – Your little glass of milk..
fdocc - … instead of the capsule,
now it will be a glass of enriched milk with the medicament.
GF – Now, I would like to ask
about the famous genetic maps that it has been talked a lot in these last years
here in Mexico.
Let’s suppose that a person knows her genetic map and knows her specific
pitfalls that she may have cardiac problems, she can be exposed to some risks,
for example, in a woman, breast cancer problems and that appears in a page… How
can the family doctor act in the face of that knowledge, I mean, what
advantages it provides him?
fdocc – Still today it is very
expensive, there’s already the technology to put in a slide thousands of genes,
their alterations and variations and when the extract is put above them, for
example of DNA taken from the blood of a person, it can be seen which genes are
the ones susceptible in a person, then, if that is detected in an early age,
obesity can be se prevented, as well as diabetes even before its first
symptoms. But, right now that continues being very expensive, but I am
confident that in the future costs are going down and this can be a general
treatment for all the people. It’ll be prevention medicine.
GF – How long it’ll take for a
baby born in the Social Security to pick his genetic CD under his arm? How
long?
fdocc – Well, the simplest thing
will be that people get conscious to see how is the family antecedent, that
will provide some idea. For example, if the family history is that my
grandfather had diabetes and my father as well, it is possible that the child
be bearing the damaged gen. Then, that gives us some idea about which genes to
look closely. All of this will tell us: O.K., I am not going to study genes related
with other aspect, for example digestion, if what I need to see is how to
control diabetes. Then, specifically I will take a lesser number of genes
related to the development of diabetes and maybe that will reduce costs and we
could be able to analyze specific genes. Because the slide with thousands of
genes is very general and even now it’s very expensive and basically it is used
more than anything to do basic research.
GF – So, it still is somehow
expensive to obtain such genetic map. How is Mexico doing in this topic? How is
the Mexican research when compared with Europe,
United Status, which are most certainly the leaders in this topic? How is Mexico doing?
fdocc – Yeah, for example this
technology of thousands of genes on a slide is very expensive and it is one of
the reasons I went to Houston,
because it was lacking here. Now it is starting to be imported and there is
available to do studies with a lesser number of genes; for example, in
Guadalajara, in the Civil Hospital, Doctor Panduro is doing a map with genetic
variations for multiple ethnical groups in Mexico and that, for me, is
something very good that doesn’t exist in any other part of the world.
GF – In none… I want to read you
some of the phone calls that we have received because it really puts us very
happy. Architect RB says "interesting talk”, he wanted you to be invited again,
if it can be a genetic program, well, hopefully we could do one. Miss LG is
marveled, fascinated with the conversation she would like you to be invited
again as "genetics is the profession of the future”, and of the present as well
¿no? So many things have already been done …
fdocc – Affirmative.
GF – JM says "where can I locate
the guest? Congratulations for the quality of the same.” We also have Miss
Lupita, "very interesting interview, please, invite him again”. Her husband is
obese and she is very interested in the issue. Yes, well, to all of us, it is
interesting to all of us. But these are not magic solutions, ¿no? There must be
a commitment by the patient’s side, right?
fdocc - Certainly, of course, and
more than anything the study of the biosciences, which is something very
beautiful. For example, here in Mexico we have more than 300 organisms
varieties of amphibians and more than one thousand two hundred of reptiles, and
for me as a researcher, there should be a lot of antidotes that if we be able
to concentrate them they must help the person for example to reduce her weight
or to control her obesity.
GF – Here you told us, for
example, of the amphibians that regenerate their extremities, or for example,
the ones that live in stagnant waters and live without any infection, that is
to say, how all of this opens a magnificent field.
fdocc – Yes it is, for example in
Patzcuaro we have this variety of amphibians Ambystoma, the Axolotl, that if
you cut one of its little feet it grows again, and at the six months you start
observing though with a smaller size the little toes totally differentiated.
The, again, if us as researchers, when the animal embryo we altered their gene,
and if then is unable to regenerate, we can see exactly which gene is the one
and study it and compare it with the human, and we could think in the future in
organ-repairs for human beings.
GF – Well Fernando, thank you
very much for visiting us, we have many, many more topics to talk and
hopefully, we hope that this thing that you can stay in Puerto Vallarta more
frequently, and that’s what all the phone calls are requesting, that we may
invite you again, so we commit you to visit us again when you’ll be back here
in Vallarta …
fdocc – Yes, I am so happy to be
able to collaborate and to talk about the biosciences and everything that they
can offer.
GF – Well, Fernando Castro
Chavez, a researcher in molecular biology developing his work there in Houston, and coming soon
here in Vallarta as well.
fdocc – God First. Thank you very
much, and thanks to the audience.
Esmeralda – Thanks Fernando, now we are going to hear
a musical …
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